发明名称 |
MULTI-PHASE EMULSIONS BASED ON AMPHIPHILIC BLOCK COPOLYMERS |
摘要 |
A method for enhancing a body's response to an immunogen is disclosed. The method comprises immunizing a subject in need thereof a vaccine composition in a water-in-oil (W/O/W) emulsion that comprises (a) an antigen; and (b) an adjuvant composition in a W/O/W emulsion. The adjuvant composition comprises: (i) a continuous aqueous phase comprising H2O; (ii) an oil phase comprising oil dispersed in the continuous aqueous phase, comprising an internal aqueous phase comprising H2O, being dispersed in the oil phase; and a physiologically acceptable lipophilic emulsifier selected from the group consisting of mannide monooleate and sorbitan esters, stabilizing the interface between the inner aqueous phase and the oil phase to form a water-in-oil (W/O) emulsion; and (iii) poly(ethylene glycol)-block-poly(lactide-co-ε-caprolactone), stabilizing the interface between the oil phase and the continuous aqueous phase.
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申请公布号 |
US2012328654(A1) |
申请公布日期 |
2012.12.27 |
申请号 |
US201213604610 |
申请日期 |
2012.09.05 |
申请人 |
HUANG MING-HSI;CHONG PELE CHOI-SING;LENG CHIH-HSIANG;LIU SHIH-JEN;CHEN HSIN-WEI;NATIONAL HEALTH RESEARCH INSTITUTES |
发明人 |
HUANG MING-HSI;CHONG PELE CHOI-SING;LENG CHIH-HSIANG;LIU SHIH-JEN;CHEN HSIN-WEI |
分类号 |
A61K39/39;A61K39/145;A61P31/16;A61P37/04 |
主分类号 |
A61K39/39 |
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