发明名称 |
CITROBACTER FREUNDII ANTIBACTERIAL AGENTS AND THEIR USE |
摘要 |
Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter freundii colicin A polypeptide, wherein the polypeptide has an antibacterial activity against the planktonic bacteria or the biofilm. Methods are also provided herein for treating a subject that has a bacterial infection, for example caused by a biofilm. The methods can be used to treat a biofilm on a living or non-living surface. Also provided herein are Citrobacter freundii colicin A polypeptides that have an antibacterial activity against planktonic bacteria or surface attached bacteria, and nucleic acid sequences encoding the polypeptides. Medical devices comprising a surface having an antimicrobial effective amount of a Citrobacter freundii colicin A polypeptide, or a nucleic acid molecule encoding the polypeptide, are also disclosed.
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申请公布号 |
US2012328684(A1) |
申请公布日期 |
2012.12.27 |
申请号 |
US201213528633 |
申请日期 |
2012.06.20 |
申请人 |
SHANKS ROBERT M.Q.;KADOURI DANIEL E.;UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY;UNIVERSITY OF PITTSBURGH - OF THE COMMONWEATH SYSTEM OF HIGHER EDUCATION |
发明人 |
SHANKS ROBERT M.Q.;KADOURI DANIEL E. |
分类号 |
A01N37/18;A01N25/34;A01P1/00;A61K38/16;A61P31/04;C07K14/195;C12N1/21;C12N15/31;C12N15/70 |
主分类号 |
A01N37/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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