ORAL THROMBIN INHIBITOR AND PREPARATION METHOD AND MEDICAL USE THEREOF

摘要

Provided are a non-peptide thrombin inhibitor as presented by formula (I), a preparation method thereof and inhibiting effect and antithrombotic effect against the thrombin. A pharmacological experiment proves that the compound of the present invention can be used to treat and prevent diseases related to thrombosis, including arterial thromboembolic disease, venous thromboembolic disease and other thrombotic cardio-cerebrovascular diseases.