发明名称 NOVEL MAYTANSINOID DERIVATIVES WITH PEPTIDE LINKER AND CONJUGATES THEREOF
摘要 The invention relates to novel cell-binding agent-cytotoxic agent conjugate having a peptide linkers and more specifically to conjugates of formula (I). The invention also provides novel cytotoxic agents of formula (II), linker compounds represented by formula (III), and drug-linker compounds represented by formula (IV). The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
申请公布号 CA2836927(A1) 申请公布日期 2012.12.27
申请号 CA20122836927 申请日期 2012.06.21
申请人 IMMUNOGEN, INC. 发明人 WIDDISON, WAYNE C.
分类号 A61K47/48;A61P35/00 主分类号 A61K47/48
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