| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula II, where Q is (CRR); nequals 1 or 2; nequals 1 or 2; nequals 1; Ris R-1or R-2, Ar is phenyl or a heteroaryl ring consisting of 8-10 carbon atoms and 1-2 heteroatoms selected from O or S; X denotes 1-2 substitutes located on Ar, each independently selected from a group consisting of OR, NRR, SR, SOR, SONRR, NRSOR, CONRR, NRC(=O)R, NRC(=O)ORand CN; R-Rdenote H; Ris H, alkyl, cyclopropyl, phenyl or pyridinyl; optionally substituted with one or more halogens or heteroatom-containing substitutes selected from a group consisting of OR, NRR, COR, CONRR, NRC(=O)Ri; Ris H or alkyl; R-Rindependently denote H, alkyl, pyridinyl or morpholinyl.EFFECT: compounds are inhibitors of rho-associated protein kinase which can be used in medicine to prevent or treat diseases or conditions associated with cytoskeleton readjustment, specifically treat high intraocular pressure such as primary open angle glaucoma.10 cl, 3 tbl, 226 ex |
