| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide tamper preventing controlled release formulations capable of preventing the separation of an opioid agonist from an opioid antagonist from dosage forms comprising the opioid agonist and the opioid antagonist by simple extraction methods, commonly used by abusers. <P>SOLUTION: A controlled release dosage form comprises a homogeneous controlled release matrix formulation comprising a hydrophobic material, comprising at least one hydrophobic polymer and at least one fatty alcohol or fatty acid, and the therapeutic amount of an opioid agonist and the sufficient amount of opioid antagonist. <P>COPYRIGHT: (C)2013,JPO&INPIT |
