发明名称 |
COMPOSITIONS AND METHODS FEATURING IL-6 AND IL-21 ANTAGONISTS |
摘要 |
<p>The present invention features compositions for inhibiting both the IL-6 and the IL-21 pathways and methods of making and using such compositions. Our work to date indicates the importance of the redundancy of IL-6 and IL-21 to perform certain crucial functions. The pathways can be inhibited by inhibiting the ligands (i.e., IL-6 and IL-21) and/or their respective receptors (i.e., the IL-6 receptor and IL-21 receptor). Alternatively, or in addition, upstream and downstream effectors in the IL-6 and IL-21 pathways can be blocked. The agents used can be antibody or antibody-based proteins or peptides including circulating receptors, optionally coupled to an immunoglobulin or a portion thereof (e.g., the Fc region). Also provided are methods for using the compositions, for example, in organ transplantation, tissue grafting, or autoimmune disorders.</p> |
申请公布号 |
WO2012012531(A9) |
申请公布日期 |
2012.12.27 |
申请号 |
WO2011US44681 |
申请日期 |
2011.07.20 |
申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER, INC.;STROM, TERRY;KOULMANDA, MARIA |
发明人 |
STROM, TERRY;KOULMANDA, MARIA |
分类号 |
C07K16/24;A61K39/395;A61P37/00;C07K14/54;C07K16/28;C07K16/46;C12N15/24 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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