摘要 |
The invention provides D02S derivatives conjugated to monosaccharide ligands directly or through a linker and optionally chelated to a metal, wherein theD02S derivatives having the following structure: wherein R1', R2' are each independently-OH or -O-alkyl; R1 is a hydrogen, a linker, or a ligand; R3 is a linker and/or a ligand; and n is an integer from 1 to 10; the linker is an amino acid, a peptide, an amino alcohol, a polyethylylene glycol, an alkyl, an alkenyl, an alkynyl, an azide, an aromatic compound, a carboxylic acid, or an ester, the alkyl, alkenyl, or alkynyl is optionally substituted with an alkyl, a halogen, a nitro group, a hydroxyl group, an amino group, or a carboxyl group; the ligand is a GLUT1 targeting moiety. |
申请人 |
RADIOMEDIX INC.;TWOROWSKA, IZABELA;SIMS-MOURTADA, JENNIFER;DELPASSAND, EBRAHIM, S. |
发明人 |
TWOROWSKA, IZABELA;SIMS-MOURTADA, JENNIFER;DELPASSAND, EBRAHIM, S. |