发明名称 |
INHIBITORS OF RECEPTOR TYROSINE KINASES (RTK) AND METHODS OF USE THEREOF |
摘要 |
The present invention provides moieties that bind to the asymmetric contact interface of a receptor tyrosine kinase (RTK), wherein the moieties inhibit ligand induced trans autophosphorylation of the RTK. The present invention also provides methods of treating or preventing an RTK-associated disease and methods for identifying moieties that bind to an asymmetric contact interface of an RTK. |
申请公布号 |
US2012328599(A1) |
申请公布日期 |
2012.12.27 |
申请号 |
US201113519837 |
申请日期 |
2011.01.13 |
申请人 |
BAE JAE HYUN;LAX IRIT;SCHLESSINGER JOSEPH;YALE UNIVERSITY |
发明人 |
BAE JAE HYUN;LAX IRIT;SCHLESSINGER JOSEPH |
分类号 |
C07K16/28;A61K31/4375;A61K31/517;A61K31/5513;A61K31/554;A61K38/16;A61K39/395;A61P19/08;A61P35/00;C07D239/90;C07D243/24;C07D281/02;C07D281/10;C07D471/04;C07K14/00;C12N5/12;G01N33/573 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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