| 发明名称 |
NOVEL C-17-HETEROARYL STEROIDAL CYP17 INHIBITOR/ANTIANDROGEN: SYNTHESIS, IN VITRO BIOLOGICAL ACTIVITY, PHARMACOKINETIC AND ANTITUMOR ACTIVITY |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide compounds which are inhibitors of human CYP17 enzyme as well as antagonists of both wild type and mutant androgen receptors (AR), and useful for the treatment of human prostate cancer. <P>SOLUTION: The 3β-hydroxy-17-(1H-benzimidazol-1-yl)androsta-5,16-diene compounds are represented by the following formula (I). <P>COPYRIGHT: (C)2013,JPO&INPIT |
| 申请公布号 |
JP2012255026(A) |
申请公布日期 |
2012.12.27 |
| 申请号 |
JP20120196525 |
申请日期 |
2012.09.06 |
| 申请人 |
UNIV OF MARYLAND BALTIMORE |
发明人 |
BRODIE ANGELA;NJAR VINCENT |
| 分类号 |
C07J43/00;A61K31/58;A61P13/08;A61P35/00 |
主分类号 |
C07J43/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
