发明名称 |
METHODS AND COMPOSITIONS FOR TARGETING SITES OF NEOVASCULAR GROWTH |
摘要 |
Compositions and methods for targeted delivery to and detection of sites of neovascular growth, including tumor vasculature, are provided. Compositions include polypeptides conjugated to or complexed with a bioactive compound, wherein the polypeptide is capable of binding to an OEC or a circulating progenitor thereof. Methods for identifying additional polypeptides with the same binding characteristics are further provided. Methods for targeted delivery of a bioactive compound to a site of neovascular growth are provided in which polypeptides capable of binding OECs or progenitors thereof are conjugated to or complexed with the bioactive compound and administered to a subject in need thereof. Methods for detecting neovascular growth are also provided, wherein the polypeptides conjugated to or complexed with a detectable label are administered to a subject and the label is detected. |
申请公布号 |
WO2012075243(A3) |
申请公布日期 |
2012.12.27 |
申请号 |
WO2011US62822 |
申请日期 |
2011.12.01 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;NORTH CAROLINA STATE UNIVERSITY;PATTERSON, CAM;VELEVA, ANKA, N. |
发明人 |
PATTERSON, CAM;VELEVA, ANKA, N. |
分类号 |
G01N33/574;A61K38/04;C07K7/04;C07K14/435;C07K14/47 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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