| 发明名称 |
3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES |
| 摘要 |
<p>The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula (I), in which: R1, R2, R3 and R4 are as defined in the Summary of the Invention. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.</p> |
| 申请公布号 |
WO2012176123(A1) |
申请公布日期 |
2012.12.27 |
| 申请号 |
WO2012IB53095 |
申请日期 |
2012.06.19 |
| 申请人 |
NOVARTIS AG;FURET, PASCAL;KALLEN, JOERG;LORBER, JULIEN;MASUYA, KEIICHI |
发明人 |
FURET, PASCAL;KALLEN, JOERG;LORBER, JULIEN;MASUYA, KEIICHI |
| 分类号 |
C07D401/14;A61K31/4178;A61P35/00;C07D403/04;C07D403/14;C07D405/14;C07D413/14;C07D417/04;C07D417/14;C07D471/10 |
主分类号 |
C07D401/14 |
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