发明名称 |
COMPOUNDS FOR PROTEASOME ENZYME INHIBITION |
摘要 |
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. |
申请公布号 |
US2012329705(A1) |
申请公布日期 |
2012.12.27 |
申请号 |
US201213492373 |
申请日期 |
2012.06.08 |
申请人 |
SMYTH MARK S.;LAIDIG GUY J. |
发明人 |
SMYTH MARK S.;LAIDIG GUY J. |
分类号 |
A61K38/06;A61P25/28;A61P29/00;A61P31/12;A61P31/18;A61P35/00;C07K5/087 |
主分类号 |
A61K38/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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