发明名称 |
METHOD FOR REDUCING MAMMALIAN ANXIETY LEVEL, METHOD FOR REDUCING ANXIETY LEVEL, USE OF DELTA-OPIOID RECEPTOR ANTAGONISTS NOT PENETRATING THROUGH BRAIN-BLOOD BARRIER FOR PREPARING ANXIOLYTIC AGENTS |
摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: present group of inventions refers to medicine, namely neurology and therapy, and concerns reducing mammalian anxiety level. That is ensured by delta-opioid receptor antagonists not penetrating through brain-blood barrier such as M-154129; ICI 154,129;N,N-Di(2-propenyl)-L-Tyr-N-[2- [[(S)-2-[[(S)-l-carboxy-3-methylbutyl]amino]-2-oxo-l- benzylethyl]thio]ethyl]-Gly-NH2.EFFECT: provided anxiolytic effect ensured by reciprocity of the peripheral and central endogenic opioid system that causes activation of the delta opioid system in the central nervous system by suppression of peripheral delta-opioid receptors in stomach.3 cl, 3 ex, 3 tbl |
申请公布号 |
RU2470661(C2) |
申请公布日期 |
2012.12.27 |
申请号 |
RU20100145995 |
申请日期 |
2010.11.11 |
申请人 |
UCHREZHDENIE ROSSIJSKOJ AKADEMII MEDITSINSKIKH NAUK NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT NORMAL'NOJ FIZIOLOGII IMENI P.K. ANOKHINA RAMN |
发明人 |
SUDAKOV SERGEJ KONSTANTINOVICH;BASHKATOVA VALENTINA GERMANOVNA;NAZAROVA GALINA ALEKSEEVNA;KOLJASNIKOVA KSENIJA NIKOLAEVNA |
分类号 |
A61K38/00;A61P25/18 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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