发明名称 |
GLP-1, EXENDIN-4, PEPTIDE ANALOGS AND USES THEREOF |
摘要 |
The invention relates to novel polypeptide analogues of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogues thereof for neuroprotective and neurotrophic effects.
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申请公布号 |
US2012329715(A1) |
申请公布日期 |
2012.12.27 |
申请号 |
US201213594313 |
申请日期 |
2012.08.24 |
申请人 |
GREIG NIGEL;EGAN JOSEPHINE;DOYLE MAIRE;HOLLOWAY HAROLD;PERRY TRACY ANN;THE GOV. OF THE US, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH & HUMAN SERVICES |
发明人 |
GREIG NIGEL;EGAN JOSEPHINE;DOYLE MAIRE;HOLLOWAY HAROLD;PERRY TRACY ANN |
分类号 |
A61K38/26;A61K38/28;A61K38/00;A61P3/10;A61P9/10;A61P19/08;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/28;A61P43/00;C07K14/47;C07K14/575;C07K14/605 |
主分类号 |
A61K38/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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