| 发明名称 |
METHODS OF IDENTIFYING OBM MODULATORS |
| 摘要 |
Novel proteins and polypeptides binding to osteoclastogenesis inhibitory factor (OCIF) (OCIF-binding molecules, OBMs) and nucleic acids encoding these proteins and polypeptides are provided. Processes for producing these proteins, polypeptides, and nucleic acid molecules by genetic engineering are provided. Medicinal compounds are provided which comprise proteins and nucleic acids according to the invention, as well as proteins which bind to OBM, including anti-OBM antibodies. These compounds may be used for the treatment of bone disease.
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| 申请公布号 |
US2012329671(A1) |
申请公布日期 |
2012.12.27 |
| 申请号 |
US201213587791 |
申请日期 |
2012.08.16 |
| 申请人 |
YAMAGUCHI KYOJI;YASUDA HISATAKA;NAKAGAWA NOBUAKI;SHIMA NOBUYUKI;KINOSAKI MASAHIKO;TSUDA EISUKE;GOTO MASAAKI;YANO KAZUKI;TOMOYASU AKIHIRO;KOBAYASHI FUMIE;WASHIDA NAOHIRO;TAKAHASHI KEN;MORINAGA TOMONORI;HIGASHIO KANJI;AMGEN INC. |
发明人 |
YAMAGUCHI KYOJI;YASUDA HISATAKA;NAKAGAWA NOBUAKI;SHIMA NOBUYUKI;KINOSAKI MASAHIKO;TSUDA EISUKE;GOTO MASAAKI;YANO KAZUKI;TOMOYASU AKIHIRO;KOBAYASHI FUMIE;WASHIDA NAOHIRO;TAKAHASHI KEN;MORINAGA TOMONORI;HIGASHIO KANJI |
| 分类号 |
C07K14/715;G01N33/53;A61K;A61K38/00;A61K39/395;A61K45/00;A61P3/14;A61P19/00;A61P19/02;A61P19/08;A61P19/10;A61P29/00;B01J20/281;C07K;C07K1/22;C07K14/47;C07K14/525;C07K14/705;C07K16/18;C07K16/28;C12N;C12N5/10;C12N5/20;C12N15/02;C12N15/09;C12N15/12;C12P;C12P21/02;C12P21/08;C12Q;C40B30/04;G01N;G01N23/00;G01N30/88;G01N33/15;G01N33/50;G01N33/543;G01N33/566;G01N33/577 |
主分类号 |
C07K14/715 |
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