ANTI-BACTERIAL AND MINERALIZING CALCIUM PHOSPHATE COMPOSITIONS

摘要

The present invention provides compositions including saturated calcium phosphate (sCaP) solutions, that may be prepared from mixtures of calcium deficient apatite (prepared by precipitation), or any calcium phosphate compounds and one or more of sodium fluoride and zinc chloride, or F or Zn ions. The solutions may be prepared from mixtures of calcium compounds (e.g., calcium carbonate, calcium fluoride) and one or more of sodium or potassium phosphates, sodium or potassium fluoride and zinc salts with, for instance, either phosphoric or hydrochloric acids. The solutions may also be prepared from mixtures of calcium compounds and one or more of sodium or potassium oxalates, sodium or potassium phosphates, sodium or potassium fluoride and zinc salts. Such compositions may be useful for and may be provided in methods for one or more of increasing occlusion of dentin tubules, decreasing bacterial attachment to dentin tubules, decreasing bacterial growth or colonization on tooth surfaces such as enamel and dentin surfaces including on dentin tubules, increasing resistance to acid dissolution, inhibiting dental caries formation and progression and tooth decay and inhibiting development of tooth hypersensitivity. In many instances, the solutions are supersaturated with respect to F- or Zn-substituted calcium phosphates, and in many instances, the solutions are supersaturated with both F- and Zn- substituted calcium phosphates.