发明名称 |
REDOX RESPONSIVE POLYMERIC NANOCAPSULES FOR PROTEIN DELIVERY |
摘要 |
The invention provides methods of making and using compositions comprising a polymer shell designed to deliver polypeptides to selected environments. In embodiments of the invention, different environmental conditions are harnessed to allow the selective degradation of the polymer shell and the consequential release of one or polypeptides encapsulated therein. In illustrative embodiments, polymer components of the shell are interconnected by disulfide-containing crosslinker moieties, linkages which maintain the integrity of the polymer shell under certain enviromental conditions including those occuring outside of cells, but degrade in an intracellular environment. |
申请公布号 |
WO2012142410(A3) |
申请公布日期 |
2012.12.27 |
申请号 |
WO2012US33515 |
申请日期 |
2012.04.13 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;TANG, YI;GU, ZHEN;ZHAO, MUXUN |
发明人 |
TANG, YI;GU, ZHEN;ZHAO, MUXUN |
分类号 |
A61K38/17;A61K9/14;A61K9/16;A61K38/16;A61K47/30;A61K47/48 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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