COMPOSITION CONTAINING MICRORNA

摘要

PURPOSE: A composition containing miRNA for controlling pigmentation gene expression is provided to suppress tyrosinase, tyrosinase-related proteins, and melan-A expression. CONSTITUTION: A composition for controlling pigmentation gene expression contains miRNA containing a base of sequence number 1 as an active ingredient. The miRNA has continuous 27 bases containing ccuucuu of sequence number 1 and a base which suppresses pigmentation gene expression. The pigmentation gene is tyrosinase, tyrosinase-related protein 1, or melan-A gene. The miRNA targets 909-915th nucleic acids of melan A mRNA 3'-UTR. The composition is a cosmetic or pharmaceutical composition for skin whitening. A composition for controlling pigmentation gene expression contains a complementary base with miRNA of sequence number 1. [Reference numerals] (AA) Relative TYR/GAPDH mRNA expression level; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) Embodiment 1