发明名称 |
METHODS OF DIAGNOSING INFLAMMATORY DISEASES BY DETERMINING PYROGLUTAMATE-MODIFIED MCP-1 AND SCREENING METHODS FOR INHIBITORS OF GLUTAMINYL CYCLASE |
摘要 |
<p>A method of monitoring treatment of an inflammatory disease or an inflammatory associated disease with the use of the ratio of N-terminal pyroglutamate modified MCP-1 (MCP-1 N1pE):total concentration of MCP-1 within a biological sample as a biomarker, and a method for determining the proportion of N-terminal pyroglutamate modified MCP-1 in relation to the total concentration of MCP-1 in biological samples. Also disclosed are a diagnostic kit and a method for screening a glutaminyl cyclase (QC) inhibitor or measuring the effectiveness of a glutaminyl cyclase (QC) inhibitor.</p> |
申请公布号 |
EP2537029(A1) |
申请公布日期 |
2012.12.26 |
申请号 |
EP20110703712 |
申请日期 |
2011.02.18 |
申请人 |
PROBIODRUG AG |
发明人 |
CYNIS, HOLGER;KLEINSCHMIDT, MARTIN;GANS, KATHRIN;RAHFELD, JENS-ULRICH;DEMUTH, HANS-ULRICH;TAUDTE, NADINE |
分类号 |
G01N33/574;G01N33/68 |
主分类号 |
G01N33/574 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|