发明名称 |
A POLYNUCLEOTIDE FOR USE IN TREATMENT OF INFLUENZA A VIRUS INDUCED DISEASES, ENCODING MODIFIED MX PROTEIN, SAID MODIFIED MX PROTEIN, AND A TRANSGENIC ANIMAL EXPRESSING GENE ENCODING MODIFIED MX PROTEIN |
摘要 |
A method can be used for treating or reducing likelihood of an influenza A virus-induced disease in a mammal. The method includes administering a polynucleotide to the mammal. Theis polynucleotide includes a gene encoding Mx protein having a TRAF2 and/or a TRAF6 binding domain. The TRAF2 and/or TRAF6 binding domain can be represented by the sequences P-X-Q/E-E, P-X-Q/E-X-X-D, or P-X-E-E-X-E. The TRAF2 and/or TRAF6 binding domain can also be located in the Mx protein in a position which corresponds to the position of the hexapeptide PEEESE in the bovine Mx1 protein or in a position which is up to 20 amino acid residues upstream or downstream of that position. |
申请公布号 |
EP2536747(A1) |
申请公布日期 |
2012.12.26 |
申请号 |
EP20100711858 |
申请日期 |
2010.02.19 |
申请人 |
UNIVERSITE DE LIEGE |
发明人 |
DESMECHT, DANIEL;CORNET, ANNE MARIE LOUISA GHISLAINE |
分类号 |
C07K14/47 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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