Inhibiting integrin receptor binding with non-native monomeric disintegrin or monomeric disintegrin domains

摘要

This invention relates to methods of inhibiting binding between a cell expressing integrin receptors specific for one or more integrins selected from the group consisting ofαIIbβ3,αvβ3,αvβ5, orα5β1, said method comprising contacting the cell with a monomeric disintegrin or monomeric disintegrin domain which comprises a C-terminal sequence non-native to the disintegrin or disintegrin domain, said C-terminal sequence encoding a functional integrin-binding loop.