发明名称 Method for combined parallel agent delivery and electroporation for cell structures an use thereof
摘要 Disclosed is a method for parallel delivery of agents to and/or into a cell structure, wherein at least two electrolyte-filled tubes are provided together with a counter electrode, the tubes being connected to a voltage or current generator, said agents being introduced into the electrolyte solution contained in the tubes, which are placed close to the cell structure, whereupon the agents are transported through the tubes to said cell structure and into the said structure through pores which have been formed by application of an electric field focused on the cell structure, resulting in electroporation of the cell structure. Also different applications of the method is disclosed, e.g. use of the method in order to transfer cell-impermeant solutes, such as drugs or genes, into the cell structure or out of the cell structure.
申请公布号 US8338150(B2) 申请公布日期 2012.12.25
申请号 US20080157369 申请日期 2008.06.09
申请人 ORWAR OWE;KARLSSON MATTIAS;NOLKRANTZ KERSTEIN;FARRE CECILIA;CELLECTRICON AB 发明人 ORWAR OWE;KARLSSON MATTIAS;NOLKRANTZ KERSTEIN;FARRE CECILIA
分类号 C12N13/00;G01N33/50;A61K31/74;A61K33/00;A61K35/12;A61K38/00;A61K38/43;A61K39/00;A61K39/395;A61K45/00;A61K48/00;A61N1/30;A61P43/00;C12N15/09;C12N15/87;G01N21/78;G01N33/15;G01N33/487;G01N33/86;G01N35/10 主分类号 C12N13/00
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