发明名称 |
Live, oral vaccine for protection against Shigella dysenteriae serotype 1 |
摘要 |
The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.
|
申请公布号 |
US8337831(B2) |
申请公布日期 |
2012.12.25 |
申请号 |
US201113285614 |
申请日期 |
2011.10.31 |
申请人 |
KOPECKO DENNIS J;XU DEQI;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRECTARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
KOPECKO DENNIS J;XU DEQI |
分类号 |
A01N63/00;C07H21/02;C07H21/04;C07K14/25;C12N15/52 |
主分类号 |
A01N63/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|