发明名称 |
2-pyridinecarboxamide derivative having GK-activating effect |
摘要 |
Compounds of a formula (I) and their pharmaceutically-acceptable salts are disclosed. The compounds have glucokinase-activating effect and are therefore useful for treatment of diabetes and obesity. R1 and R2 each independently represent a lower alkyl group; X1 represent a group of a formula (II-1): wherein: R11 and R12 each independently represent a hydrogen atom or a lower alkyl group, or taken together with the nitrogen atom to which they bond, R11 and R12 may form a 4- to 7-membered nitrogen-containing aliphatic ring (one carbon atom constituting the 4- to 7-membered nitrogen-containing aliphatic ring may be replaced by an oxygen atom), or taken together with a carbon atom in (CH2)m, R11 and R12 may form a 4- to 7-membered nitrogen-containing aliphatic ring; m indicates an integer of from 1 to 3. |
申请公布号 |
US8338460(B2) |
申请公布日期 |
2012.12.25 |
申请号 |
US20070973240 |
申请日期 |
2007.10.05 |
申请人 |
HASHIMOTO NORIAKI;SAGARA YUFU;ASAI MASANORI;NISHIMURA TERUYUKI;MSD K. K. |
发明人 |
HASHIMOTO NORIAKI;SAGARA YUFU;ASAI MASANORI;NISHIMURA TERUYUKI |
分类号 |
A61K31/433;A61K31/4439;C07D417/10;C07D417/14 |
主分类号 |
A61K31/433 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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