发明名称 |
Cut-point in PTEN protein expression that accurately identifies tumors and is predictive of drug response to a pan-ErbB inhibitor |
摘要 |
A cut-point in the quantitative measurement of PTEN protein expression that accurately identifies tumors with two inactivated alleles of the PTEN gene. Patients with a normalized PTEN score of PTEN null will be treated with a pan-ErbB tyrosine kinase inhibitor. A normalized PTEN protein expression score is obtained by comparing the tumor PTEN OD expression value with the non-malignant PTEN OD expression value. |
申请公布号 |
US8338456(B2) |
申请公布日期 |
2012.12.25 |
申请号 |
US20110984043 |
申请日期 |
2011.01.04 |
申请人 |
COUGHLIN CHRISTINA MARIE;FEINGOLD JAY MARSHALL;JOHNSTON DANIEL STEPHEN;BERKENBLIT ANNA;STRAHS ANDREW LOUIS;ZACHARCHUK CHARLES MICHAEL;WYETH LLC |
发明人 |
COUGHLIN CHRISTINA MARIE;FEINGOLD JAY MARSHALL;JOHNSTON DANIEL STEPHEN;BERKENBLIT ANNA;STRAHS ANDREW LOUIS;ZACHARCHUK CHARLES MICHAEL |
分类号 |
A61K31/4709;A61P35/00;G01N1/30;G01N33/53 |
主分类号 |
A61K31/4709 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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