| 摘要 |
<p>Provided is a modified matrix type serine protease I (MT-SP1) polypeptide or a catalytically active portion thereof, comprising an amino acid replacement in a position corresponding to a position selected from among positions 23, 52, 60(g), 65, 71, 93, 95, 126, 129, 131, 136, 143, 144, 154, 164, 166, 184(a), 201, 209, 230, 234, and 244 , based on chymotrypsin numbering, whereby substrate specificity or activity is altered compared to the MT-SP1 polypeptide not containing the amino acid replacement(s). The peptide can be used to treat diseases mediated by compliment protein C2.</p> |
