| 摘要 |
Disclosed herein are quinazoline derivatives of general formula (I) in which: each of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, independently, is H, halo, nitro, amino, cyano, hydroxy, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, alkoxy, alkylthio, alkylcarbonyl, carboxy, alkoxycarbonyl, carbonylamino, sulfonylamino, aminocarbonyl, or aminosulfonyl, or R3 and R4, together with the carbon atoms to which they are attached, form a 4- to 7- membered saturated, unsaturated, or aromatic ring, optionally containing 1-3 hetero atoms selected from N, O and S; X is O, S, or NR, wherein R is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, or aminosulfonyl; and Z is N; for inhibiting vascular endothelial growth factor receptor activity, for use in the treatment of an angiogenesis-related disorder, such as cancer, age-related macula degeneration, or chronic inflammatory disease.
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