发明名称 |
ANTI-ANGPTL3 ANTIBODIES AND USES THEREOF |
摘要 |
A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits or interferes with at least one activity of human angiopoietin-like protein 3 (hANGPTL3) is provided. The human anti-hANGPTL3 antibodies are useful in treating diseases or disorders associated with ANGPTL3, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. Furthermore, the anti-hANGPTL3 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders, for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases; acute pancreatitis; nonalcoholic steatohepatitis (NASH); diabetes; obesity; and the like. |
申请公布号 |
WO2012174178(A1) |
申请公布日期 |
2012.12.20 |
申请号 |
WO2012US42338 |
申请日期 |
2012.06.14 |
申请人 |
REGENERON PHARMACEUTICALS, INC;SLEEMAN, MARK, W.;GUSAROVA, VIKTORIA;MURPHY, ANDREW, J. |
发明人 |
SLEEMAN, MARK, W.;GUSAROVA, VIKTORIA;MURPHY, ANDREW, J. |
分类号 |
C07K16/22;A61K39/395;A61P3/06 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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