CORD BLOOD-DERIVED NEURONS BY EXPRESSION OF SOX2

摘要

Provided herein are induced neural progenitors cells generated from cord blood (CB-iNPCs). CB-iNPCs are generated by ectopic expression of SOX2, optionally in combination with c-MYC. CB-iNPCs differentiate into functional, mature neurons in vitro and in vivo. The mature CB-derived neurons form functional synapses, generate action potentials, and produce neurons when grafted in vivo. Thus, further provided herein are cell-base therapies for neurodegenerative diseases and traumatic injuries to the nervous system.