发明名称 |
BIOMARKER FOR AMYOTROPHIC LATERAL SCLEROSIS AND DIAGNOSTIC KIT AND METHOD USED THEREOF |
摘要 |
A diagnostic marker for determining of a patient with amyotrophic lateral sclerosis (ALS), comprising an autoantibody against a human protein HMGB1 is described. A diagnostic kit for determining of a patient with ALS, comprising: (a) an HMGB1 protein; and (b) an HMGB1 antibody standard is also presented. A method of determining ALS in a subject, comprising the steps: (a) detecting autoantibody against HMGB1 in a biological sample taken from the subject and normal control individuals; and (b) statistically comparing concentrations of the autoantibody against HMGB1 in the subject with that of the normal control individuals obtained from step (a); wherein a higher concentration of the autoantibody against HMGB1 in the subject than a cut-off concentration indicates the subject suffers from ALS is further described. |
申请公布号 |
US2012322082(A1) |
申请公布日期 |
2012.12.20 |
申请号 |
US201113164190 |
申请日期 |
2011.06.20 |
申请人 |
CHANG HAO-TENG;CHANG MARGARET DAH-TSYR;HWANG CHI-SHIN;CHINA MEDICAL UNIVERSITY;NATIONAL TSING HUA UNIVERSITY |
发明人 |
CHANG HAO-TENG;CHANG MARGARET DAH-TSYR;HWANG CHI-SHIN |
分类号 |
G01N33/566;C07K16/18 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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