发明名称 METHOD OF PREDICTING HEMATOGENOUS METASTASES IN INTESTINAL TYPE OF STOMACH CANCER
摘要 FIELD: medicine.SUBSTANCE: invention relates to field of medicine and is intended for prediction of hematogenous metastases in intestinal type of stomach cancer. Immunohistochemical assessment of percent of expression of aldo-keto reductase family I member B10 (AKR1B10) protein in cells of intestinal type stomach cancer, forming glandular-like structures, located in mucous, submucous, muscular and serous layers of stomach wall, is performed. Regression coefficient ? is calculated by method of multiple regression from software package Statistica 6,0 for Windows. If regression coefficient ? value equals or is larger than "-0.25", case is referred to group of high risk of development of hematogenous metastases, if regression coefficient ? value is less than "-0.25", case is referred to group of low risk of development of hematogenous metastases.EFFECT: method makes it possible to increase accuracy of predicting risk of hematogenous metastases in case of intestinal type of stomach cancer.2 ex, 5 dwg, 2 tbl
申请公布号 RU2470308(C1) 申请公布日期 2012.12.20
申请号 RU20110134537 申请日期 2011.08.17
申请人 FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE "NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT ONKOLOGII"SIBIRSKOGO OTDELENIJA ROSSIJSKOJ AKADEMII MEDITSINSKIKH NAUK (FGBU "NII ONKOLOGII" SO RAMN);UCHREZHDENIE ROSSIJSKOJ AKADEMII NAUK INSTITUT MOLEKULJARNOJ BIOLOGII IM. V.A. EHNGEL'GARDA RAN (IMB RAN) 发明人 ZAV'JALOVA MARINA VIKTOROVNA;PEREL'MUTER VLADIMIR MIKHAJLOVICH;STEPANOV IVAN VADIMOVICH;VTORUSHIN SERGEJ VLADIMIROVICH;CHERDYNTSEVA NADEZHDA VIKTOROVNA;LITVJAKOV NIKOLAJ VASIL'EVICH;AFANAS'EV SERGEJ GENNAD'EVICH;AVGUSTINOVICH ALEKSANDRA VLADIMIROVNA;SAVENKOVA OL'GA VLADIMIROVNA;GRIGOR'EVA EVGENIJA SERGEEVNA;BERESTEN' SERGEJ FEDOROVICH;VOLKOMOROV VIKTOR VLADIMIROVICH
分类号 G01N33/53 主分类号 G01N33/53
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