发明名称 |
VECTORS AND METHODS FOR LONG-TERM IMMUNE EVASION TO PROLONG TRANPLANT VIABILITY |
摘要 |
A method can include making one or more compositions for altering allogeneic cells of a human donor for a human recipient by identifying at least one mismatch in an HLA protein between the human donor and the human recipient; determining a consensus conserved nucleic acid sequence among nucleic acid sequences encoding a domain having the mismatch or among domains having a plurality of mismatches; and forming at least one of the one or more compositions by constructing a virus vector for expressing a sequence targeting the consensus conserved nucleic acid sequence, which when expressed in cells functions as a negative modulator for nucleic acid encoding the domain having the mismatch or the domains having the plurality of mismatches.
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申请公布号 |
US2012321598(A1) |
申请公布日期 |
2012.12.20 |
申请号 |
US201213567064 |
申请日期 |
2012.08.05 |
申请人 |
CICCIARELLI JAMES C.;KASAHARA NORIYUKI;LOGG CHRISTOPHER R.;NATIONAL INSTITUTE OF TRANSPLANTATION FOUNDATION |
发明人 |
CICCIARELLI JAMES C.;KASAHARA NORIYUKI;LOGG CHRISTOPHER R. |
分类号 |
A61K35/12;A61K39/00;A61K48/00;A61P37/08;C12N5/08;C12N15/63;C12N15/64;C12N15/65;C12N15/86;C12N15/867;C12Q1/02 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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