METHODS FOR PRODUCING PANCREATIC PRECURSOR CELLS AND USES THEREOF
摘要
The present invention is directed to methods for readily propagating somatic pancreatic precursor cells. The methods comprise isolating cells from intact pancreatic samples and enhancing guanine nucleotide (GNP) biosynthesis in cultures comprising these cells, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kinetics in the cells, thereby generating pancreatic precursor cells.
申请公布号
WO2012174365(A2)
申请公布日期
2012.12.20
申请号
WO2012US42644
申请日期
2012.06.15
申请人
BOSTON BIOMEDICAL RESEARCH INSTITUTE, INC.;SHERLEY, JAMES, L.;PARE, JEAN-FRANCOIS