发明名称 |
SYSTEMS AND METHODS FOR DETECTING AND QUANTIFYING A SEQUENCE OF NUCLEOTIDES |
摘要 |
Methods and systems of quantifying a target material in solution include detection of a size change of a hybridized nanoparticle. In particular, the examples include functionalizing a plurality of nanoparticles to adapt the nanoparticles to hybridize with a species-specific target material, measuring the size of the functionalized nanoparticles to predetermine a standard distribution of non-hybridized nanoparticles, introducing the functionalized nanoparticles in a solution containing species-specific target materials and/or non-target materials, and hybridizing the functionalized nanoparticles with the species-specific target material if present in the solution. The size of the nanoparticles in solution are then measured after hybridization, and the presence or non-presence of the species-specific target material is detected and/or quantified by comparing the measured size of the nanoparticles after hybridization to the standard distribution of non-hybridized nanoparticles. |
申请公布号 |
WO2012148960(A3) |
申请公布日期 |
2012.12.20 |
申请号 |
WO2012US34899 |
申请日期 |
2012.04.25 |
申请人 |
UNIVERSITY OF NOTRE DAME DU LAC;RUGGIERO, STEVEN;TANNER, CAROL |
发明人 |
RUGGIERO, STEVEN;TANNER, CAROL |
分类号 |
G01N33/53;G01N21/47;G01N21/59 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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