COMPOSITION CONTAINING BEE VENOM PHOSPHOLIPASE AS ACTIVE INGREDIENT FOR TREATMENT OF PRION DISEASE

摘要

The present invention relates to a composition containing bee venom phospholipase A2 (group ? sPLA2)isolated from bee venom as an active ingredient, which enables the treatment of neurodegenerative disorders by regulating the expression of AKT or p-38 MAPK kinase, thereby inhibiting neuronal cell death caused by modified prion proteins. According to the present invention, the composition containing Group sPLA as an active ingredient can regulate the activity of a neurodegeneration factors, and the neuronal cell death caused by modified prion proteins can be effectively inhibited; and thus, the composition can be used as a pharmaceutical composition for the prevention and treatment of neurodegenerative disorders.