PHOSPHONIUM-CONTAINING POLYELECTROLYTES FOR NONVIRAL GENE DELIVERY

摘要

The present invention provides compositions comprising polymers and biologically active compounds, especially polymeric drug delivery systems. More specifically, the present invention provides ammonium and/or phosphonium-containing polymers and/or block copolymers as a viable and improved option for gene delivery. In an embodiment, the present invention provides a method of using a composition comprising a block copolymer that comprises: a stabilization block and a complexation block, and optionally an endosomolytic block for nonviral gene delivery. Preferred compositions include such co-polymers, wherein the complexation block is chosen from polymers of styrenic-based phosphonium-containing monomers chosen from: (F) wherein X is phosphorus; R is Cl-24 alkyl; and n is a number ranging from 2 to 1,000.