发明名称 |
Enhanced Cytotoxicity of Anti-CD74 and Anti-HLA-DR Antibodies with Interferon-Gamma |
摘要 |
Disclosed herein are methods and compositions comprising interferon-γ(IFN-γ) and anti-CD74 or anti-HLA-DR antibodies. In preferred embodiments, the IFN-γincreases the expression of CD74 and/or HLA-DR in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 or anti-HLA-DR antibodies. The compositions and methods are of use to treat diseases involving CD74+ and/or HLA-DR+ cells, such as cancer cells, autoimmune disease cells or immune dysfunction disease cells.
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申请公布号 |
US2012321556(A1) |
申请公布日期 |
2012.12.20 |
申请号 |
US201213567226 |
申请日期 |
2012.08.06 |
申请人 |
BURTON JACK D.;STEIN RHONA;GOLDENBERG DAVID M.;IMMUNOMEDICS, INC.;CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY |
发明人 |
BURTON JACK D.;STEIN RHONA;GOLDENBERG DAVID M. |
分类号 |
A61K39/395;A61K38/19;A61K38/20;A61K51/10;A61P1/04;A61P1/16;A61P3/10;A61P19/02;A61P35/00;A61P35/02;A61P37/00;A61P37/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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