发明名称 |
Novel Method for the Preparation of Stavudine Polymorphic Form I and Form II |
摘要 |
A novel method for the preparation of stavudine polymorphic form I and form II is described. 5′-acetate-2′,3′-diacetyl-5-methyluridine is reacted with catalytic amounts of sodium methoxide in a C1-C4 alcoholic solvent, resulting in crude stavudine form II. Crude stavudine form II can be converted into polymorphic stavudine form I by slurry at reflux in isopropanol, without isolating or purifying the crude stavudine form II. |
申请公布号 |
US2012322996(A1) |
申请公布日期 |
2012.12.20 |
申请号 |
US20070160629 |
申请日期 |
2007.02.26 |
申请人 |
DI LERNIA GIANLUCA;MANCINI ALFREDO;MANCINI FRANCO;SERRA MAURIZIO;VERGANI DOMENICO |
发明人 |
DI LERNIA GIANLUCA;MANCINI ALFREDO;MANCINI FRANCO;SERRA MAURIZIO;VERGANI DOMENICO |
分类号 |
C07H1/00 |
主分类号 |
C07H1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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