THERAPEUTIC AGENT FOR HEART DISEASES AND CELL SHEET FOR TREATING HEART DISEASES

摘要

It was discovered that a peptide having an amino acid sequence represented by formula (I), (II), (III), or (IV) has a cardiac function-improving effect. The peptide or a pharmaceutically acceptable salt thereof is useful as an active ingredient of a therapeutic agent for heart diseases. Further, when a cell sheet for treating heart diseases, which secretes the peptide, is transplanted into the heart suffering from a heart disease, the peptide can be allowed to act on the target site for a long time. X1-X2-Val-Tyr-X5-X6 (I) X2-Val-Tyr-X5-X6-X7 (II) Ser-X2-X3-(Tyr/Phe/Trp)-X5-X6 (III) X2-X3-(Tyr/Phe/Trp)-X5-X6-Arg (IV) In formulae (I), (II), (III), and (IV), X1, X2, X3, X5, X6, and X7 are the same or different and represent an arbitrary amino acid residue.