发明名称 |
SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS |
摘要 |
A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a non-naturally occurring bifunctional inhibitor molecule including (a) protein binding moiety, and (b) an effector region, wherein the protein binding moiety binds to a blocking protein, and wherein the effector region binds to the target protein in order to bind the target protein and the blocking protein and prevent access of the binding protein to the target protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
申请公布号 |
WO2012174489(A2) |
申请公布日期 |
2012.12.20 |
申请号 |
WO2012US42827 |
申请日期 |
2012.06.15 |
申请人 |
THE OHIO STATE UNIVERSITY;BRIESEWITZ, ROGER;PEI, DEHUA;WU, XIANGHONG |
发明人 |
BRIESEWITZ, ROGER;PEI, DEHUA;WU, XIANGHONG |
分类号 |
A61K38/12 |
主分类号 |
A61K38/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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