发明名称 |
ANTIGEN-SPECIFIC CENTRAL-MEMORY T CELL PREPARATIONS HAVING HIGH CD4+ FRACTION |
摘要 |
<p>The invention relates to a method for generation of T cell preparations that are specific for at least one target antigen, comprising the steps of expanding lymphoid cells in vitro in the presence of a target antigen or peptide fragments thereof in an expansion step, isolating cells that secrete interferon gamma and culturing, the cells in the presence of interleukin 2 and interleukin 7 and either an inhibitor of the mTOR Complex 1, or in the presence of an inhibitor of IL-2/IL-2R interaction. The invention further relates to preparations obtained by the method of the invention.</p> |
申请公布号 |
WO2012171882(A1) |
申请公布日期 |
2012.12.20 |
申请号 |
WO2012EP61041 |
申请日期 |
2012.06.11 |
申请人 |
VOLK, HANS-DIETER;SCHMUECK, MICHAEL;REINKE, PETRA |
发明人 |
VOLK, HANS-DIETER;SCHMUECK, MICHAEL;REINKE, PETRA |
分类号 |
C12N5/0783 |
主分类号 |
C12N5/0783 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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