CORTICOSTEROID-BASED COMPOSITION WITH CONTROLLED RELEASE FOR TREATMENT OF EAR DISEASES

摘要

FIELD: medicine.SUBSTANCE: pharmaceutical composition, suitable for application in treatment of ear diseases includes acceptable for ear thermoreversable water gel. Pharmaceutical composition consists of anti-inflammatory corticosteroid in form of multiple particles and polyoxypropylene and polyoxyethylene-based polymer. Composition is introduced locally to the subject, suffering from ear disease, by intratympanic introduction on membrane of cochlea window or near it.EFFECT: composition in accordance with invention ensures prolonged release of anti-inflammatory corticosteroid through membrane of cochlea window into inner ear cochlea during, at least, 5 days after a single introduction.12 cl, 9 dwg, 9 tbl, 31 ex