| 摘要 |
The RPAP1 gene product is expressed in multiple stem cell niches, regulates stem cell differentiation and represses iPS reprogramming. Thus, it can be used as a marker of pluripotent or multipotent cells, such as embryonic, or adult stem cells and induced pluripotent cells. Its suppression or inhibition can be used to increase the efficiency of the transformation of more differentiated cells, such as fibroblast, into induced pluripotent cells, as well as to increase the number of pluripotent cells in cultures of stem cells. |
| 申请人 |
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III;CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS;SERRANO MARUGAN, MANUEL;LYNCH, CIAN JOSEPH;ROJO DE LA VIESCA, ENRIQUE;SANMARTIN ARTINANO, MARIA MAITE;SANCHEZ SERRANO, JOSE JUAN |
发明人 |
SERRANO MARUGAN, MANUEL;LYNCH, CIAN JOSEPH;ROJO DE LA VIESCA, ENRIQUE;SANMARTIN ARTINANO, MARIA MAITE;SANCHEZ SERRANO, JOSE JUAN |
