发明名称 |
PROTEIN DOMAINS AND USES THEREFOR |
摘要 |
<p>The present disclosure relates generally to a structure-modeling approach to identify therapeutic and diagnostic targets on proteins. Means are provided to generate agents which bind and optionally antagonize a particular domain within a protein referred to as a Cleaved_Adhesin Family Domain. In an embodiment, the disclosure is directed to the control of Porphyromonas gingivalis infection or infection by related microorganisms by targeting selected domains on protease-like molecules having a hemagglutinin region. In another embodiment, the present invention enables the modulation or detection of a protein having a Cleaved_Adhesin domain homologous to those in the protease-like molecules.</p> |
申请公布号 |
EP2533794(A1) |
申请公布日期 |
2012.12.19 |
申请号 |
EP20110741763 |
申请日期 |
2011.02.11 |
申请人 |
THE UNIVERSITY OF SYDNEY;SYDNEY WEST AREA HEALTH SERVICE (SWAHS) |
发明人 |
COLLYER, CHARLES;HUNTER, NEIL |
分类号 |
A61K38/02;A61K38/55;A61P1/02;A61P31/04;C40B30/02;G06F19/16;G06F19/18 |
主分类号 |
A61K38/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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