发明名称 |
1,2,3-TRIAZOLE-BASED PEPTIDOMIMETIC INTEGRIN INHIBITORS FOR THE DIAGNOSIS AND THERAPY OF TUMORS |
摘要 |
The present invention refers to the field of chemical compounds bearing a 1,2,3-triazole ring of formula (I) and possessing guanidino and carboxylic groups or their isosteres, their preparation by Cu-catalyzed “click-chemistry”, and medical-diagnostic use in pathologies where angiogenesis is altered, for example pathologic conditions of tumor origin, tumor metastasis, osteoporosis, and rheumatoid arthritis. |
申请公布号 |
EP2534138(A1) |
申请公布日期 |
2012.12.19 |
申请号 |
EP20110708421 |
申请日期 |
2011.02.14 |
申请人 |
UNIVERSITA' DEGLI STUDI DI FIRENZE |
发明人 |
GUARNA, ANTONIO;MENCHI, GLORIA;CINI, NICOLETTA;TRABOCCHI, ANDREA;PUPI, ALBERTO;BOTTONCETTI, ANNA;RASPANTI, SILVIA;CALORINI, LIDO |
分类号 |
C07D249/04;A61K31/4192;A61K38/05;A61P19/00;A61P35/00;C07D403/12;C07D409/12;C07K5/02 |
主分类号 |
C07D249/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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