发明名称 |
3-HYDROXYPYRROLIDINE INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND NUCLEOSIDASE |
摘要 |
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (I) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds. |
申请公布号 |
EP2454263(A4) |
申请公布日期 |
2012.12.19 |
申请号 |
EP20100800093 |
申请日期 |
2010.07.16 |
申请人 |
THE ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY;INDUSTRIAL RESEARCH LIMITED |
发明人 |
EVANS, GARY BRIAN;LONGSHAW, ALISTAIR IAN;SCHRAMM, VERN L.;TYLER, PETER, CHARLES |
分类号 |
C07D487/04;A61K31/519;A61P31/04;A61P35/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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