发明名称 |
MEANS AND METHODS FOR BREAKING NONCOVALENT BINDING INTERACTIONS BETWEEN MOLECULES |
摘要 |
<p>The present invention concerns multimeric proteinaceous molecules comprising at least two members that bind each other via a region of noncovalent interaction, wherein a first of said members comprises a conditionally reactive group that, when activated, cleaves a covalent bond within said first member. Cleavage of the covalent bond results in a reduction in the binding strength with which the at least two members bind to each other via said region of noncovalent interaction. The reduction in the binding strength can result in the separation of the members under mild conditions.</p> |
申请公布号 |
EP1841791(B1) |
申请公布日期 |
2012.12.19 |
申请号 |
EP20060716584 |
申请日期 |
2006.01.25 |
申请人 |
STICHTING HET NEDERLANDS KANKER INSTITUUT;STICHTING SANQUIN BLOEDVOORZIENING |
发明人 |
OVAA, HUIB;SCHUMACHER, ANTONIUS NICOLAAS MARIA |
分类号 |
C07K14/705;C07K19/00 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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