发明名称 |
COMPOSITIONS AND METHODS FOR TREATMENT OF EAR DISORDERS |
摘要 |
The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject. |
申请公布号 |
EP2293800(A4) |
申请公布日期 |
2012.12.19 |
申请号 |
EP20090758028 |
申请日期 |
2009.06.07 |
申请人 |
QUARK PHARMACEUTICALS, INC. |
发明人 |
ALPERT, EGVENIA;SPIVAK, IGOR;BAR-ILAN, AMIR |
分类号 |
A61K31/70;A61K9/00 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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