发明名称 |
METHOD FOR PRODUCING RECOMBINANT VIRUS |
摘要 |
<p>To provide a method for producing, at high purity, a recombinant baculovirus which exhibits intended immunogenicity and is useful for a pharmaceutical (e.g., a vaccine), a transfer vector for use in the production of the recombinant baculovirus, and a method for producing the transfer vector. The method for producing a transfer vector which includes therein a fusion gene containing at least one gene encoding a virus-particle-forming protein and a gene encoding a foreign immunogenic protein, the method including modifying the polynucleotide sequence of the gene encoding the virus-particle-forming protein so as not to alter the amino acid residues constituting a corresponding naturally occurring virus-particle-forming protein and/or modifying the polynucleotide sequence of the gene so that a portion of the amino acid residues constituting the naturally occurring virus-particle-forming protein is deleted.</p> |
申请公布号 |
EP2535409(A1) |
申请公布日期 |
2012.12.19 |
申请号 |
EP20110742284 |
申请日期 |
2011.02.10 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
KAWASAKI, MASANORI;INAGAKI, KATSUYA;MIZUKOSHI, MASAMI |
分类号 |
C12N15/09;A61K39/00;C07K14/005;C12N7/00;C12N15/117;C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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